* Noah Wyle as Dr. John Carter - Attending Physician
* Laura Innes as Dr. Kerry Weaver - Chief of Staff
* Mekhi Phifer as Dr. Greg Pratt - Second Year Resident
* Alex Kingston as Dr. Elizabeth Corday - Chief of Surgery
* Goran Visnjic as Dr. Luka Kovač - Attending Physician
* Maura Tierney as Abby Lockhart - Nurse Manager/Fourth Year Medical Student ...